abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative su...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Q,Huang Y,Qin C,Liang M,Mao X,Li S,Zou Y,Jia W,Li H,Ma CW,Huang Z

更新日期：2016-01-01 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B)...

journal_title：Oxidative medicine and cellular longevity

authors： Žitňanová I,Šiarnik P,Kollár B,Chomová M,Pazderová P,Andrezálová L,Ježovičová M,Koňariková K,Laubertová L,Krivošíková Z,Slezáková L,Turčáni P

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reporte...

journal_title：Oxidative medicine and cellular longevity

authors： Giudice A,D'Arena G,Crispo A,Tecce MF,Nocerino F,Grimaldi M,Rotondo E,D'Ursi AM,Scrima M,Galdiero M,Ciliberto G,Capunzo M,Franci G,Barbieri A,Bimonte S,Montella M

更新日期：2016-01-01 00:00:00

abstract：:Benzene is a chemical contaminant widespread in industrial and living environments. The oxidative metabolites of benzene induce toxicity involving oxidative damage. Protecting cells and cell membranes from oxidative damage, glucose-6-phosphate dehydrogenase (G6PD) maintains the reduced state of glutathione (GSH). This...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Cao M,Yang W,Sun F,Xu C,Yin L,Pu Y

更新日期：2016-01-01 00:00:00

abstract：:Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of this study was to investigate the antioxidant effects of sulforaphane (SFN) in a rat model of CIN and a cell model of oxidative stress in HK2 cells. Methods. Rats were randomized into four groups ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Z,Liao G,Zhou Q,Lv D,Holthfer H,Zou H

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a ...

journal_title：Oxidative medicine and cellular longevity

authors： Tang Y,Li J,Gao C,Xu Y,Li Y,Yu X,Wang J,Liu L,Yao P

更新日期：2016-01-01 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:Purpose. To investigate the preventive effect of resveratrol (RES) on the formation of portal vein system thrombosis (PVST) in a rat fibrosis model. Methods. A total of 64 male SD rats, weighing 200-300 g, were divided into five groups: Sham operation, Splenectomy I, Splenectomy II, RES, and low molecular weight hepar...

journal_title：Oxidative medicine and cellular longevity

authors： Xu M,Xue W,Ma Z,Bai J,Wu S

更新日期：2016-01-01 00:00:00

abstract：:To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

journal_title：Oxidative medicine and cellular longevity

authors： Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

更新日期：2016-01-01 00:00:00

abstract：:The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as...

journal_title：Oxidative medicine and cellular longevity

authors： Prokopieva VD,Yarygina EG,Bokhan NA,Ivanova SA

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic ef...

journal_title：Oxidative medicine and cellular longevity

authors： Ficarra S,Russo A,Barreca D,Giunta E,Galtieri A,Tellone E

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea. We tested whether peroxynitrite (ONOO(-)), a highly reactive nitrogen species, is involved in the enhanced...

journal_title：Oxidative medicine and cellular longevity

authors： Moya EA,Arias P,Varela C,Oyarce MP,Del Rio R,Iturriaga R

更新日期：2016-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00

abstract：:Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and ...

journal_title：Oxidative medicine and cellular longevity

authors： Shang Y,Siow YL,Isaak CK,O K

更新日期：2016-01-01 00:00:00

abstract：:The influence of a water-soluble [60] fullerene derivative containing five residues of 3-phenylpropionic acid and a chlorine addend appended to the carbon cage (F-828) on serum-starving human embryo lung diploid fibroblasts (HELFs) was studied. Serum deprivation evokes oxidative stress in HELFs. Cultivation of serum-s...

journal_title：Oxidative medicine and cellular longevity

authors： Ershova ES,Sergeeva VA,Tabakov VJ,Kameneva LA,Porokhovnik LN,Voronov II,Khakina EA,Troshin PA,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2016-01-01 00:00:00

abstract：:We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo...

journal_title：Oxidative medicine and cellular longevity

authors： Huang Y,Zhao H,Cao K,Sun D,Yang Y,Liu C,Cui J,Cheng Y,Li B,Cai J,Gao F

更新日期：2016-01-01 00:00:00

abstract：:Viruses play an important role in cancerogenesis. It is estimated that approximately 20% of all cancers are linked to infectious agents. The viral genes modulate the physiological machinery of infected cells that lead to cell transformation and development of cancer. One of the important adoptive responses by the canc...

journal_title：Oxidative medicine and cellular longevity

authors： Mushtaq M,Darekar S,Kashuba E

更新日期：2016-01-01 00:00:00

abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

更新日期：2016-01-01 00:00:00

abstract：:The widely used herbicide atrazine (ATR) can cause many adverse effects including immunotoxicity, but the underlying mechanisms are not fully understood. The current study investigated the role of oxidative stress and calcium homeostasis in ATR-induced immunotoxicity in mice. ATR at doses of 0, 100, 200, or 400 mg/kg ...

journal_title：Oxidative medicine and cellular longevity

authors： Gao S,Wang Z,Zhang C,Jia L,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to evaluate the properties of internal components of erythrocytes in chronic renal failure (CRF) patients undergoing hemodialysis (HD) in comparison to control subjects. For investigation of conformational state of hemoglobin and nonheme proteins (NHP) the maleimide spin label (MSL) in electr...

journal_title：Oxidative medicine and cellular longevity

authors： Pieniazek A,Gwozdzinski K

更新日期：2015-01-01 00:00:00

abstract：:Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) i...

journal_title：Oxidative medicine and cellular longevity

authors： Carreira BP,Santos DF,Santos AI,Carvalho CM,Araújo IM

更新日期：2015-01-01 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：SCOPE:To determine whether doses of quercetin in the range of serum concentrations exert any effect on triacylglycerol accumulation in maturing preadipocytes and mature adipocytes. The influence on the expression of adipogenic markers as well as on gene expression and activity of enzymes involved in triacylglycerol met...

journal_title：Oxidative medicine and cellular longevity

authors： Eseberri I,Miranda J,Lasa A,Churruca I,Portillo MP

更新日期：2015-01-01 00:00:00

abstract：:With recent insight into the mechanisms involved in diseases, such as cardiovascular disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of treatment are now being assessed. Traditional medicine including the use of natural products is widely practiced around the world, assuming tha...

journal_title：Oxidative medicine and cellular longevity

authors： Shay J,Elbaz HA,Lee I,Zielske SP,Malek MH,Hüttemann M

更新日期：2015-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical event...

journal_title：Oxidative medicine and cellular longevity

authors： Angeloni C,Prata C,Dalla Sega FV,Piperno R,Hrelia S

更新日期：2015-01-01 00:00:00

abstract：:Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence. CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well...

journal_title：Oxidative medicine and cellular longevity

authors： Dando I,Cordani M,Dalla Pozza E,Biondani G,Donadelli M,Palmieri M

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration. Pathogenetic mechanisms, triggered by β-amyloid (Aβ) accumulation, include oxidative stress, derived from energy homeostasis deregulation and involving mitochondria and peroxisomes. We here addressed the oxida...

journal_title：Oxidative medicine and cellular longevity

authors： Porcellotti S,Fanelli F,Fracassi A,Sepe S,Cecconi F,Bernardi C,Cimini A,Cerù MP,Moreno S

更新日期：2015-01-01 00:00:00

abstract：:The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

journal_title：Oxidative medicine and cellular longevity

authors： Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

更新日期：2015-01-01 00:00:00

abstract：:Aluminum ions are especially toxic to plants in acidic soils. Here we present evidences that SO2 protects germinating wheat grains against aluminum stress. SO2 donor (NaHSO3/Na2SO3) pretreatment at 1.2 mM reduced the accumulation of superoxide anion, hydrogen peroxide, and malondialdehyde, enhanced the activities of g...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu DB,Hu KD,Guo XK,Liu Y,Hu LY,Li YH,Wang SH,Zhang H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The human Circadian Locomotor Output Cycle protein Kaput (CLOCK) gene was originally discovered as a regulator of essential human daily rhythms. This seemingly innocuous gene was then found to be associated with a multitude of human malignancies, via several biochemical pathways. We aimed to further investig...

journal_title：Oxidative medicine and cellular longevity

authors： Tang X,Guo D,Lin C,Shi Z,Qian R,Fu W,Liu J,Li X,Fan L

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder characterized by movement alterations caused by reduced dopaminergic neurotransmission in the nigrostriatal pathway, presumably by oxidative stress (OS). MPP(+) intrastriatal injection leads to the overproduction of free radicals (FR). The increasing formation of FR ...

journal_title：Oxidative medicine and cellular longevity

authors： Rubio-Osornio M,Gorostieta-Salas E,Montes S,Pérez-Severiano F,Rubio C,Gómez C,Ríos C,Guevara J

更新日期：2015-01-01 00:00:00

abstract：:Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen...

journal_title：Oxidative medicine and cellular longevity

authors： Ferrari RS,Andrade CF

更新日期：2015-01-01 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a ce...

journal_title：Oxidative medicine and cellular longevity

authors： Büchter C,Zhao L,Havermann S,Honnen S,Fritz G,Proksch P,Wätjen W

更新日期：2015-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) regulate bone marrow microenvironment for stem and progenitor cells functions including self-renewal, differentiation, and cell senescence. In response to ischemia, ROS also play a critical role in mediating the mobilization of endothelial progenitor cells (EPCs) from the bone marrow to t...

journal_title：Oxidative medicine and cellular longevity

authors： Lam YT

更新日期：2015-01-01 00:00:00

abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...

journal_title：Oxidative medicine and cellular longevity

authors： Wang P,Li CG,Qi Z,Cui D,Ding S

更新日期：2015-01-01 00:00:00

abstract：:Organophosphate pesticides (OPs) are among the most widely used synthetic chemicals for the control of a wide variety of pests, and reactive oxygen species (ROS) caused by OPs may be involved in the toxicity of various pesticides. Previous studies have demonstrated that a reactivation of latent Epstein-Barr virus (EBV...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao L,Xie F,Wang TT,Liu MY,Li JL,Shang L,Deng ZX,Zhao PX,Ma XM

更新日期：2015-01-01 00:00:00

abstract：:The cystine/glutamate exchanger (system xc (-)) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system xc (-) can potentially cause excitotoxicity. However, through providing cystine to the cell, it regulates the levels of cellular glutathione (GSH), the main endogeno...

journal_title：Oxidative medicine and cellular longevity

authors： Albano R,Raddatz NJ,Hjelmhaug J,Baker DA,Lobner D

更新日期：2015-01-01 00:00:00